25 Life Technologies
™
| Genome editing
Working with stem cells? Check out these new resources!
Stem cell engineering resources
• On-demand webinar: Watch this webinar as
we examine genetic engineering of iPSCs
derived from Parkinson's disease samples,
which provide model systems to study disease
mechanisms in cell types not previously available.
• White paper: Parkinson's disease cell models—part 3: Genome editing of
Parkinson's disease donor-derived iPSC lines using GeneArt
®
Precision
TAL technology
• Video: Moving forward: future directions for understanding
Parkinson's disease
Figure 6. TAL effector DNA-binding domain. The structure of the DNA-binding domain can be manipulated to
produce a protein domain that binds specifically to any DNA sequence in the genome. TAL effector repeats can be
assembled modularly, varying the RVDs to create a TAL protein that recognizes a specific target DNA sequence.
Linking the repeats is straightforward, and long TAL effectors can be designed to specifically target any locus in
the genome.
Repeat-variable di-residues (RVD)
Genome editing of Parkinson's disease donor-derived iPSC lines
using GeneArt
®
Precision TALs technology
Parkinson's disease cell models—part 3
