32 Life Technologies
™
| Genome editing
Site-specific gene integration tools
Targeted integration of your gene of interest into specific integration
Jump-In
™
targeted integration kits
Efficiently produce high-expressing mammalian cell lines
Whether you are experienced at cell engineering or need engineered cells for
your projects, the Jump-In
™
cell engineering platform can accelerate your projects
by enabling you to generate engineered cell lines in much less time than traditional
methods. Jump-In
™
technology helps accelerate stable cell line development via
the targeted integration of genetic material into specific integration sites using
PhiC31 integrase.
Unlike better-known recombinases such as Cre and Flp, PhiC31 integrase catalyzes
recombination between two nonidentical sites and, because it lacks a corresponding
excision enzyme, makes the integration unidirectional and virtually irreversible. In
addition, combining PhiC31 with R4 integrase allows for isogenic expression from
a defined genomic locus, providing the ideal solution for comparative analysis of
gene families, isoforms, or orthologs. Depending on your needs and experience, we
offer multiple options for accessing Jump-In
™
technology, allowing you to choose the
method that best uses your available resources and fits your desired timelines.
Find out more at lifetechnologies.com/jumpin
