24 Life Technologies
™
| Genome editing
Technology overview
Transcription activator–like (TAL) effector proteins are produced by bacteria in
the genus Xanthomonas, which are widely distributed plant pathogens. Natural
TAL effectors bind to specific sequences of host DNA, altering the infected plant's
gene expression in ways that further the disease process. The natural TAL effector
proteins have two distinct domains: an effector domain and an extraordinarily
specific DNA-binding domain. The DNA-binding domain consists of a variable
number of amino acid repeats (Figure 6). Each repeat contains 33–35 amino
acids and recognizes a single DNA base pair. The DNA recognition occurs via 2
hypervariable amino acid residues at positions 12 and 13 within each repeat, called
repeat-variable di-residues (RVDs).
Watch this online tutorial, presented by Dr. Jon Chesnut, research fellow and R&D lead, to learn more about
GeneArt
®
Precision TAL technology.
TAL effector technology
Precise and extraordinarily flexible genome editing
