40 Life Technologies
™
| Genome editing
mirVana
™
miRNA mimics and inhibitors
For artificial regulation of target mRNA translation
mirVana
™
miRNA mimics and inhibitors are chemically modified, synthetic
nucleic acids designed to either mimic mature miRNAs, or to bind to and inhibit
endogenous miRNAs. These products provide a means to functionally study the
role of specific miRNAs within cellular systems, or to validate the role of miRNAs
in regulating target genes. mirVana
™
miRNA mimics and inhibitors have been
validated with Lipofectamine
®
RNAiMAX Transfection Reagent for use in cell-based
systems, and with Invivofectamine
®
2.0 Reagent for in vivo delivery. In vivo–ready
mirVana
™
miRNA mimics and inhibitors have been purified by HPLC and dialysis,
making them ready for immediate use. mirVana
™
miRNA mimics and inhibitors are:
• Versatile—functionally study specific miRNAs using in vitro or in vivo systems
• Potent—validate miRNA regulation of gene expression with minimal off-target
effects (Figure 10)
• High throughput–compatible—generate libraries for effective screening of
multiple miRNAs simultaneously
• Current—content is regularly updated based on the miRBase miRNA database
Gene modulation RNAi tools
Transient knockdown of multiple transcripts
